Stress-related catecholamines have a role in cancer and β-adrenoceptors, specifically β2-adrenoceptors have been identified as new targets in treating melanoma. Recently, β3-adrenoceptors have shown a pleiotropic effect on melanoma microenvironment leading to cancer progression. However, the mechanisms by which β3-adrenoceptors promote this progression remain poorly understood. Catecholamines affect the immune system by modulating several factors that can alter immune cell sub-population homeostasis. Understanding the mechanisms of cancer immune-tolerance is one of the most intriguing challenges in modern research. This study investigates the potential role of β3-adrenoceptors in immune-tolerance regulation.
β3-adrenoceptor as a potential immuno-suppressor agent in melanoma / Calvani, M., Bruno, G., Dal Monte, M., Nassini, R., Fontani, F., Casini, A., Cavallini, L., Becatti, M., Bianchini, F., De Logu, F., Forni, G., la Marca, G., Calorini, L., Bagnoli, P., Chiarugi, P., Pupi, A., Azzari, C., Geppetti, P., Favre, C., Filippi, L.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 1476-5381. - STAMPA. - 176:(2019), pp. 2509-2524. [10.1111/bph.14660]
β3-adrenoceptor as a potential immuno-suppressor agent in melanoma
Bruno, Gennaro;Nassini, Romina;Fontani, Filippo;Casini, Arianna;Becatti, Matteo;Bianchini, Francesca;De Logu, Francesco;la Marca, Giancarlo;Calorini, Lido;Bagnoli, Paola;Chiarugi, Paola;Pupi, Alberto;Azzari, Chiara;Geppetti, Pierangelo;Filippi, Luca
2019
Abstract
Stress-related catecholamines have a role in cancer and β-adrenoceptors, specifically β2-adrenoceptors have been identified as new targets in treating melanoma. Recently, β3-adrenoceptors have shown a pleiotropic effect on melanoma microenvironment leading to cancer progression. However, the mechanisms by which β3-adrenoceptors promote this progression remain poorly understood. Catecholamines affect the immune system by modulating several factors that can alter immune cell sub-population homeostasis. Understanding the mechanisms of cancer immune-tolerance is one of the most intriguing challenges in modern research. This study investigates the potential role of β3-adrenoceptors in immune-tolerance regulation.
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