The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.
Structural Characterization of a Gold/Serum Albumin Complex / Pratesi, Alessandro; Cirri, Damiano; Fregona, Dolores; Ferraro, Giarita; Giorgio, Anna; Merlino, Antonello; Messori, Luigi. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - STAMPA. - 58:(2019), pp. 10616-10619. [10.1021/acs.inorgchem.9b01900]
Structural Characterization of a Gold/Serum Albumin Complex
Pratesi, Alessandro;Cirri, Damiano;Ferraro, Giarita;Merlino, Antonello
;Messori, Luigi
2019
Abstract
The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.
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