Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function / Fawcett JW, Oohashi T, Pizzorusso T.. - In: NATURE REVIEWS. NEUROSCIENCE. - ISSN 1471-003X. - STAMPA. - 20:(2019), pp. 451-465. [10.1038/s41583-019-0196-3]

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function.

Pizzorusso T.
2019

Abstract

Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
2019
20
451
465
Goal 3: Good health and well-being for people
Fawcett JW, Oohashi T, Pizzorusso T.
File in questo prodotto:
File Dimensione Formato  
Fawcett_V4_for_referees_1546516946_10.docx

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 463.64 kB
Formato Microsoft Word XML
463.64 kB Microsoft Word XML   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1171693
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 285
  • ???jsp.display-item.citation.isi??? 262
social impact