The aldehyde–amine–alkyne (A3) coupling reaction is a powerful multicomponent coupling reaction for the build/couple/pair approach in diversity‐oriented synthesis (DOS), herein demonstrated by the application of Boc‐prolinal for the synthesis of pyrrolidine‐based molecular scaffolds bearing a propargylamine chemical handle.

Copper-Catalyzed A3-Coupling for the Diversity-Oriented Synthesis of Proline-Derived Alkynyl-Substituted Peptidomimetic Scaffolds / Innocenti, Riccardo; Lenci, Elena; Baldini, Lorenzo; Faggi, Cristina; Menchi, Gloria; Trabocchi, Andrea. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 2019:(2019), pp. 6203-6210. [10.1002/ejoc.201900703]

Copper-Catalyzed A3-Coupling for the Diversity-Oriented Synthesis of Proline-Derived Alkynyl-Substituted Peptidomimetic Scaffolds

Innocenti, Riccardo;Lenci, Elena;Baldini, Lorenzo;Faggi, Cristina;Menchi, Gloria;Trabocchi, Andrea
2019

Abstract

The aldehyde–amine–alkyne (A3) coupling reaction is a powerful multicomponent coupling reaction for the build/couple/pair approach in diversity‐oriented synthesis (DOS), herein demonstrated by the application of Boc‐prolinal for the synthesis of pyrrolidine‐based molecular scaffolds bearing a propargylamine chemical handle.
2019
2019
6203
6210
Innocenti, Riccardo; Lenci, Elena; Baldini, Lorenzo; Faggi, Cristina; Menchi, Gloria; Trabocchi, Andrea
1a - Articolo su rivista
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1173075
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