Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature.

Tubule repair: with a little help from my “unexpected” friends / De Chiara L.; Romagnani P.. - In: KIDNEY INTERNATIONAL. - ISSN 0085-2538. - STAMPA. - 95:(2019), pp. 487-489. [10.1016/j.kint.2018.11.019]

Tubule repair: with a little help from my “unexpected” friends

DE CHIARA, LETIZIA
Writing – Original Draft Preparation
;
Romagnani P.
Writing – Review & Editing
2019

Abstract

Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature.
2019
95
487
489
De Chiara L.; Romagnani P.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1174962
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