Ethnopharmacological relevance: Posidonia oceanica (L.) Delile is an endemic seagrass of the Mediterranean Sea whose use has been documented as a traditional herbal remedy for diabetes and hypertension. Our recently described Posidonia oceanica leaves extract is a phytocomplex endowed with interesting bioactivities, including the inibitory property on human cancer cell migration. Aim of the study: The aim of this study was to investigate the anti-inflammatory effects of P. oceanica extract underlying its mechanism of action. Materials and methods: We explored the anti-inflammatory effects of P. oceanica extract on RAW264.7 murine macrophages activated by LPS. We investigated the reactive oxygen species (ROS) and nitric oxide (NO) production and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Then, we examined P. oceanica extract role on the regulation of NF-κB signaling pathway. Results: P. oceanica phytocomplex exhibited a strong ability to inhibit oxidative stress by affecting the production of both ROS and NO and to reduce iNOS and COX-2 levels. In addition, it was evidenced its anti-inflammatory role via inhibiting NF-κB signaling pathway through modulation of ERK1/2 and Akt intracellular cascades. Conclusions: Our results recognize an anti-inflammatory role of P. oceanica phytocomplex particularly emphasizing its cell safe mechanism of action. In conclusion, the marine plant P. oceanica may be of great interest for scientific research as a source of promising molecules for designing alternative strategies to the conventional treatment of inflammatory diseases.

Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile / Vasarri M.; Leri M.; Barletta E.; Ramazzotti M.; Marzocchini R.; Degl'Innocenti D.. - In: JOURNAL OF ETHNOPHARMACOLOGY. - ISSN 0378-8741. - ELETTRONICO. - 247:(2020), pp. 112252-112259. [10.1016/j.jep.2019.112252]

Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile

Vasarri M.;Leri M.;Barletta E.;Ramazzotti M.;Marzocchini R.;Degl'Innocenti D.
2020

Abstract

Ethnopharmacological relevance: Posidonia oceanica (L.) Delile is an endemic seagrass of the Mediterranean Sea whose use has been documented as a traditional herbal remedy for diabetes and hypertension. Our recently described Posidonia oceanica leaves extract is a phytocomplex endowed with interesting bioactivities, including the inibitory property on human cancer cell migration. Aim of the study: The aim of this study was to investigate the anti-inflammatory effects of P. oceanica extract underlying its mechanism of action. Materials and methods: We explored the anti-inflammatory effects of P. oceanica extract on RAW264.7 murine macrophages activated by LPS. We investigated the reactive oxygen species (ROS) and nitric oxide (NO) production and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Then, we examined P. oceanica extract role on the regulation of NF-κB signaling pathway. Results: P. oceanica phytocomplex exhibited a strong ability to inhibit oxidative stress by affecting the production of both ROS and NO and to reduce iNOS and COX-2 levels. In addition, it was evidenced its anti-inflammatory role via inhibiting NF-κB signaling pathway through modulation of ERK1/2 and Akt intracellular cascades. Conclusions: Our results recognize an anti-inflammatory role of P. oceanica phytocomplex particularly emphasizing its cell safe mechanism of action. In conclusion, the marine plant P. oceanica may be of great interest for scientific research as a source of promising molecules for designing alternative strategies to the conventional treatment of inflammatory diseases.
2020
247
112252
112259
Vasarri M.; Leri M.; Barletta E.; Ramazzotti M.; Marzocchini R.; Degl'Innocenti D.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1175162
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 29
social impact