A series of 7-dimethylaminovinylpyrazolo[1,5-a]pyrimidines bearing an acetyl or an ethoxycarbonyl group at the 6-position turned out to be useful intermediates for the synthesis of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 8H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepines. These tricyclic derivatives were studied for their affinity for the central benzodiazepine receptor, and meaningful suggestions about the structure-affinity relationship were obtained. Some of the above intermediates were also reacted with S-methylthiourea, to give a mixture of pyrazolo[5',1':1,2]pyrimido[5,6-e][1,3]diazocines and pyrazolo[1,5-a]quinazolines.
Synthesis of 7-(2-dimethylaminovinyl) derivatives of pyrazolo[1,5-a]pyrimidines, as precursors of new tricyclic series. Binding studies of BDZ receptor / Bruni F.; Costanzo A.; Selleri S.; Guerrini G.; Giusti L.; Martini C.; Lucacchini A.. - In: IL FARMACO. - ISSN 0014-827X. - ELETTRONICO. - 48:(1993), pp. 309-319.
Synthesis of 7-(2-dimethylaminovinyl) derivatives of pyrazolo[1,5-a]pyrimidines, as precursors of new tricyclic series. Binding studies of BDZ receptor
Bruni F.;Costanzo A.
;Selleri S.;
1993
Abstract
A series of 7-dimethylaminovinylpyrazolo[1,5-a]pyrimidines bearing an acetyl or an ethoxycarbonyl group at the 6-position turned out to be useful intermediates for the synthesis of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 8H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepines. These tricyclic derivatives were studied for their affinity for the central benzodiazepine receptor, and meaningful suggestions about the structure-affinity relationship were obtained. Some of the above intermediates were also reacted with S-methylthiourea, to give a mixture of pyrazolo[5',1':1,2]pyrimido[5,6-e][1,3]diazocines and pyrazolo[1,5-a]quinazolines.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.