A series of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidin‐6‐ones was obtained by reaction of ammonium acetate with ethyl 7‐dimethylaminovinylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylates and these had been prepared from ethyl 7‐methylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylates by reaction with dimethylformamide dimethylacetal. Under these conditions the compounds bearing a 2‐hydroxy group were also O‐alkylated. During the preparation of the ethyl 2‐hydroxy‐7‐methyl‐3‐phenylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylate the corresponding 5‐methyl isomer was isolated and identified.
Reactivity of 7‐(2‐dimethylaminovinyl)pyrazolo[1,5‐a]pyrimidines: Synthesis of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine derivatives as potential benzodiazepine receptor ligands. 2 / Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Casilli M.L.; Giusti L.. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 1943-5193. - ELETTRONICO. - 32:(1995), pp. 291-298. [10.1002/jhet.5570320149]
Reactivity of 7‐(2‐dimethylaminovinyl)pyrazolo[1,5‐a]pyrimidines: Synthesis of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine derivatives as potential benzodiazepine receptor ligands. 2
Bruni F.;Selleri S.;Costanzo A.;
1995
Abstract
A series of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidin‐6‐ones was obtained by reaction of ammonium acetate with ethyl 7‐dimethylaminovinylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylates and these had been prepared from ethyl 7‐methylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylates by reaction with dimethylformamide dimethylacetal. Under these conditions the compounds bearing a 2‐hydroxy group were also O‐alkylated. During the preparation of the ethyl 2‐hydroxy‐7‐methyl‐3‐phenylpyrazolo[1,5‐a]pyrimidine‐6‐carboxylate the corresponding 5‐methyl isomer was isolated and identified.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.