Various 3-,7-,8-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their 5-deoxyderivatives were prepared to investigate their antimicrobial, anti HIV-1 and antiproliferative activities. Derivatives bearing electron-withdrawing groups at the 3-,7- and 3-,8-positions showed antiproliferative activity against human neoplastic cell lines. Several compounds displayed antibacterial and antifungal activities, although at lower concentrations than those cytotoxic for lymphoblastoid cells.
Antiproliferative and antimicrobial activities of pyrazolo[5,1- c][1,2,4]benzotriazine 5-oxides and their 5-deoxyderivatives / Costanzo A.; Ciciani G.; Guerrini G.; Bruni F.; Selleri S.; Donato R.; Sacco C.; Musiu C.; Milia C.; Longu S.; Minnei C.; La Colla P.. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - ELETTRONICO. - 9:(1999), pp. 223-238.
Antiproliferative and antimicrobial activities of pyrazolo[5,1- c][1,2,4]benzotriazine 5-oxides and their 5-deoxyderivatives
Costanzo A.;Ciciani G.;Bruni F.;Selleri S.;Donato R.;Sacco C.;
1999
Abstract
Various 3-,7-,8-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their 5-deoxyderivatives were prepared to investigate their antimicrobial, anti HIV-1 and antiproliferative activities. Derivatives bearing electron-withdrawing groups at the 3-,7- and 3-,8-positions showed antiproliferative activity against human neoplastic cell lines. Several compounds displayed antibacterial and antifungal activities, although at lower concentrations than those cytotoxic for lymphoblastoid cells.
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