Compared with <1 in 200 otherwise healthy adults, QT prolongation (QTc > 480 ms) was present in 1 out of 8 patients with HCM. The QTc was partly reflective of the degree of cardiac hypertrophy and left ventricular outflow tract obstruction. Because of its pro-arrhythmic potential and its potential relevance to management and risk stratification, routine QTc assessment should be performed in patients with HCM, particularly when concomitant use of QT-prolonging medications is considered.
Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy / Johnson J.N.; Grifoni C.; Bos J.M.; Saber-Ayad M.; Ommen S.R.; Nistri S.; Cecchi F.; Olivotto I.; Ackerman M.J.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 32:(2011), pp. 1114-1120. [10.1093/eurheartj/ehr021]
Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy
Grifoni C.;Nistri S.;Cecchi F.;Olivotto I.;
2011
Abstract
Compared with <1 in 200 otherwise healthy adults, QT prolongation (QTc > 480 ms) was present in 1 out of 8 patients with HCM. The QTc was partly reflective of the degree of cardiac hypertrophy and left ventricular outflow tract obstruction. Because of its pro-arrhythmic potential and its potential relevance to management and risk stratification, routine QTc assessment should be performed in patients with HCM, particularly when concomitant use of QT-prolonging medications is considered.
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