The study confirms previously found robust heritability for electrical traits like QTc in LQTS, and adds information on low or lacking heritability for structural traits in heritable cardiomyopathies. This may steer the search for genetic modifiers in heritable cardiac disease.
Heritability in genetic heart disease: The role of genetic background / Jansweijer J.A.; Van Spaendonck-Zwarts K.Y.; Tanck M.W.T.; Peter Van Tintelen J.; Christiaans I.; Van Der Smagt J.; Vermeer A.; Bos J.M.; Moss A.J.; Swan H.; Priori S.; Rydberg A.; Tfelt-Hansen J.; Ackerman M.; Olivotto I.; Charron P.; Gimeno J.R.; Van Den Berg M.; Wilde A.; Pinto Y.M.. - In: OPEN HEART. - ISSN 2053-3624. - ELETTRONICO. - 6:(2019), pp. 0-0. [10.1136/openhrt-2018-000929]
Heritability in genetic heart disease: The role of genetic background
Olivotto I.;
2019
Abstract
The study confirms previously found robust heritability for electrical traits like QTc in LQTS, and adds information on low or lacking heritability for structural traits in heritable cardiomyopathies. This may steer the search for genetic modifiers in heritable cardiac disease.
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