A personalized approach to therapy has great promise to improve disease outcomes. To this end, the identification of different subsets of patients according with the prevalent pathogenic process might guide in the choice of therapeutic strategy. We hypothesize that UC patients might be stratified according to distinctive cytokine profiles and/or to a specific mucosa-associated microbiota.
IL-13 mRNA tissue content identifies two subsets of adult ulcerative colitis patients with different clinical and mucosa-associated microbiota profiles / Butera, Alessia; Di Paola, Monica; Vitali, Francesco; De Nitto, Daniela; Covotta, Francesco; Borrini, Francesco; Pica, Roberta; De Filippo, Carlotta; Cavalieri, Duccio; Giuliani, Alessandro; Pronio, Annamaria; Boirivant, Monica. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - ELETTRONICO. - (2019), pp. 154-197. [10.1093/ecco-jcc/jjz154]
IL-13 mRNA tissue content identifies two subsets of adult ulcerative colitis patients with different clinical and mucosa-associated microbiota profiles
Di Paola, Monica;De Filippo, Carlotta;Cavalieri, Duccio;
2019
Abstract
A personalized approach to therapy has great promise to improve disease outcomes. To this end, the identification of different subsets of patients according with the prevalent pathogenic process might guide in the choice of therapeutic strategy. We hypothesize that UC patients might be stratified according to distinctive cytokine profiles and/or to a specific mucosa-associated microbiota.
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