Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens action potentials, thus reducing cellular arrhythmias. The electrophysiological profile of disopyramide explains the efficient reduction of outflow gradients but also the limited prolongation of the QT interval and the absence of arrhythmic side effects observed in 39 disopyramide-treated patients. In conclusion, our results support the idea that disopyramide is safe for outpatient use in obstructive patients.

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: a Translational Study / Coppini, Raffaele; Ferrantini, Cecilia; Pioner, Josè Manuel; Santini, Lorenzo; Wang, Zhinuo J.; Palandri, Chiara; Scardigli, Marina; Vitale, Giulia; Sacconi, Leonardo; Stefàno, Pierluigi; Flink, Laura; Riedy, Katherine; Pavone, Francesco Saverio; Cerbai, Elisabetta; Poggesi, Corrado; Mugelli, Alessandro; Bueno-Orovio, Alfonso; Olivotto, Iacopo; Sherrid, Mark V.. - In: JACC. BASIC TO TRANSLATIONAL SCIENCE. - ISSN 2452-302X. - ELETTRONICO. - (2019), pp. 0-0. [10.1016/j.jacbts.2019.06.004]

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: a Translational Study

Coppini, Raffaele;Ferrantini, Cecilia;Pioner, Josè Manuel;Santini, Lorenzo;Palandri, Chiara;Scardigli, Marina;VITALE, GIULIA;Sacconi, Leonardo;Stefàno, Pierluigi;Pavone, Francesco Saverio;Cerbai, Elisabetta;Poggesi, Corrado;Mugelli, Alessandro;Olivotto, Iacopo;
2019

Abstract

Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens action potentials, thus reducing cellular arrhythmias. The electrophysiological profile of disopyramide explains the efficient reduction of outflow gradients but also the limited prolongation of the QT interval and the absence of arrhythmic side effects observed in 39 disopyramide-treated patients. In conclusion, our results support the idea that disopyramide is safe for outpatient use in obstructive patients.
2019
0
0
Coppini, Raffaele; Ferrantini, Cecilia; Pioner, Josè Manuel; Santini, Lorenzo; Wang, Zhinuo J.; Palandri, Chiara; Scardigli, Marina; Vitale, Giulia; Sacconi, Leonardo; Stefàno, Pierluigi; Flink, Laura; Riedy, Katherine; Pavone, Francesco Saverio; Cerbai, Elisabetta; Poggesi, Corrado; Mugelli, Alessandro; Bueno-Orovio, Alfonso; Olivotto, Iacopo; Sherrid, Mark V.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1176886
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