Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual variability in on-treatment platelet inhibition (e.g. CYP2C19*2), evidence that these variants have clinical utility to predict major adverse cardiovascular events remains controversial.
Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients / Lewis, Joshua P; Backman, Joshua D; Reny, Jean-Luc; Bergmeijer, Thomas O; Mitchell, Braxton D; Ritchie, Marylyn D; Déry, Jean-Pierre; Pakyz, Ruth E; Gong, Li; Ryan, Kathleen; Kim, Eun-Young; Aradi, Daniel; Fernandez-Cadenas, Israel; Lee, Ming Ta Michael; Whaley, Ryan M; Montaner, Joan; Gensini, Gian Franco; Cleator, John H; Chang, Kiyuk; Holmvang, Lene; Hochholzer, Willibald; Roden, Dan M; Winter, Stefan; Altman, Russ; Alexopoulos, Dimitrios; Kim, Ho-Sook; Gawaz, Meinrad; Bliden, Kevin; Valgimigli, Marco; Marcucci, Rossella; Campo, Gianluca; Schaeffeler, Elke; Dridi, Nadia P; Wen, Ming-Shien; Shin, Jae Gook; Fontana, Pierre; Giusti, Betti; Geisler, Tobias; Kubo, Michiaki; Trenk, Dietmar; Siller-Matula, Jolanta M; Ten Berg, Jurriën M; Gurbel, Paul A; Schwab, Matthias; Klein, Teri E; Shuldiner, Alan R. - In: EUROPEAN HEART JOURNAL. CARDIOVASCULAR PHARMACOTHERAPY. - ISSN 2055-6837. - ELETTRONICO. - 6:(2020), pp. 203-210. [10.1093/ehjcvp/pvz045]
Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients
Gensini, Gian Franco;Marcucci, Rossella;Giusti, Betti;
2020
Abstract
Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual variability in on-treatment platelet inhibition (e.g. CYP2C19*2), evidence that these variants have clinical utility to predict major adverse cardiovascular events remains controversial.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Lewis 2020.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
972.8 kB
Formato
Adobe PDF
|
972.8 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
