CLINICAL CHARACTERISTICS OF PATIENTS WITH NEGATIVE INTERIM-PET AND POSITIVE FINAL PET: DATA FROM THE PROSPECTIVE PET-ORIENTED HD0801 STUDY BY FONDAZIONE ITALIANA LINFOMI (FIL)

Rigacci, L.; Puccini, B.; Zinzani, P.; Kovalchuk, S.; Broccoli, A.; Evangelista, A.; Gioia, D.; Mannelli, L.; Castagnoli, A.; Santoro, A.; Bonfichi, M.; Rossi, G.; Anastasia, A.; Zaja, F.; Vitolo, U.; Pavone, V.; Pulsoni, A.; Gaidano, G.; Stelitano, C.; Salvi, F.; Rusconi, C.; Tani, M.; Freilone, R.; Borsatti, E.; Levis, A.

doi:10.1002/hon.2437_19

Interim‐PET (i‐PET) has shown an high prognostic impact in the definition of ABVD efficacy in advanced stage Hodgkin Lymphoma (HL). Patients with negative i‐PET but with a positive PET at the end of therapy had a very bad prognosis even in comparison with i‐PET positive patients salvaged with intensification of therapy. From our study only LDH value at diagnosis was associated with a significant probability to have a positive PET6, none of the other clinical characteristics were associated with this result. Probably biological and pathological markers could be associated with i‐PET to increase the predictive power but in particular to reduce the false negative i‐PET.

CLINICAL CHARACTERISTICS OF PATIENTS WITH NEGATIVE INTERIM-PET AND POSITIVE FINAL PET: DATA FROM THE PROSPECTIVE PET-ORIENTED HD0801 STUDY BY FONDAZIONE ITALIANA LINFOMI (FIL) / Rigacci, L.; Puccini, B.; Zinzani, P.; Kovalchuk, S.; Broccoli, A.; Evangelista, A.; Gioia, D.; Mannelli, L.; Castagnoli, A.; Santoro, A.; Bonfichi, M.; Rossi, G.; Anastasia, A.; Zaja, F.; Vitolo, U.; Pavone, V.; Pulsoni, A.; Gaidano, G.; Stelitano, C.; Salvi, F.; Rusconi, C.; Tani, M.; Freilone, R.; Borsatti, E.; Levis, A.. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - ELETTRONICO. - 35:(2017), pp. 38-38. [10.1002/hon.2437_19]