Nuclear Receptors in the Regulation of Lipid Metabolism

Altered regulation of energy metabolism is the hallmark of many diseases that have a significant burden of cardiovascular events. Diabetes, metabolic syndrome, and dyslipidemias are important risk factors for the development of cardiovascular disease. Balancing energy metabolism to meet the body’s fuel request requires the tight coordination of many different processes in different organs and cell types. Nuclear receptors act as master regulators of these complex processes due to their ability to integrate intra- and extracellular metabolic and signalling pathways. Thus, they represent key pharmacologic targets to address metabolic disorders. This review briefly summarizes the regulation of lipid metabolism by nuclear receptors and discusses the recent advances in this highly dynamic field.