5-year overall survival of stage III colorectal cancer (CRC) patients (pts) treated with standard adjuvant chemotherapy (CHT) (fluoropyrimidine-FP with/without oxaliplatin-OHP) is still unsatisfactory and highly variable (42-88%). Although single molecular biomarkers and molecular signatures predictive of adjuvant CHT outcome have been identified in CRC, none of them has been validated. We hypothesized that differences in gene expression may be responsible for the variability of prognosis of stage III CRC pts. The goal of this study was to identify molecular biomarkers predictive of response to FP-based adjuvant CHT in stage III CRC pts.

D13Global gene expression profile reveals a distinct transcriptomic profile predictive of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy / Tassi, R.; Mini, E.; D'Aurizio, R.; Perrone, G.; Magi, A.; Lapucci, A.; Napoli, C.; Picariello, L.; Brugia, M.; Landini, I.; Mazzei, T.; Tonelli, F.; Nobili, S.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 27:(2016), pp. iv43-iv43. [10.1093/annonc/mdw335.13]

D13Global gene expression profile reveals a distinct transcriptomic profile predictive of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy

Mini, E.;D'Aurizio, R.;Magi, A.;Lapucci, A.;Napoli, C.;Picariello, L.;Brugia, M.;Mazzei, T.;Nobili, S.
2016

Abstract

5-year overall survival of stage III colorectal cancer (CRC) patients (pts) treated with standard adjuvant chemotherapy (CHT) (fluoropyrimidine-FP with/without oxaliplatin-OHP) is still unsatisfactory and highly variable (42-88%). Although single molecular biomarkers and molecular signatures predictive of adjuvant CHT outcome have been identified in CRC, none of them has been validated. We hypothesized that differences in gene expression may be responsible for the variability of prognosis of stage III CRC pts. The goal of this study was to identify molecular biomarkers predictive of response to FP-based adjuvant CHT in stage III CRC pts.
2016
27
iv43
iv43
Goal 3: Good health and well-being for people
Tassi, R.; Mini, E.; D'Aurizio, R.; Perrone, G.; Magi, A.; Lapucci, A.; Napoli, C.; Picariello, L.; Brugia, M.; Landini, I.; Mazzei, T.; Tonelli, F.; Nobili, S.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1179833
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