USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

Costa, Lionel; Corre, Sébastien; Michel, Valérie; Le Luel, Krysten; Fernandes, Julien; Ziveri, Jason; Jouvion, Gregory; Danckaert, Anne; Mouchet, Nicolas; Da Silva Barreira, David; Torres, Javier; Camorlinga, Margarita; D'Elios, Mario Milco; Fiette, Laurence; De Reuse, Hilde; Galibert, Marie-Dominique; Touati, ELIETTE CAMILLE

doi:10.1136/gutjnl-2019-318640

Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-mediated USF1 deregulation impacts p53-response and consequently genetic instability. We also explored in vivo the role of USF1 in gastric carcinogenesis.

USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis / Costa, Lionel; Corre, Sébastien; Michel, Valérie; Le Luel, Krysten; Fernandes, Julien; Ziveri, Jason; Jouvion, Gregory; Danckaert, Anne; Mouchet, Nicolas; Da Silva Barreira, David; Torres, Javier; Camorlinga, Margarita; D'Elios, Mario Milco; Fiette, Laurence; De Reuse, Hilde; Galibert, Marie-Dominique; Touati, Eliette. - In: GUT. - ISSN 0017-5749. - ELETTRONICO. - (2019), pp. gutjnl-2019-318640-0. [10.1136/gutjnl-2019-318640]