hERG1 is aberrantly expressed in human GD samples and has an impact on both PFS and OS, hence representing a novel prognostic marker for progression of GD towards GC of the intestinal histotype. Once properly validated, hERG1 detection could be included in the clinical practice, during endoscopic surveillance protocols, for the management of GD at higher risk of progression, as already proposed for Barrett's oesophagus.
The hERG1 potassium channel behaves as prognostic factor in gastric dysplasia endoscopic samples / Lastraioli E.; Romoli M.R.; Iorio J.; Lottini T.; Chiudinelli M.; Bencivenga M.; Vindigni C.; Tomezzoli A.; De Manzoni G.; Compagnoni B.; Manzi I.; Messerini L.; Saragoni L.; Arcangeli A.. - In: ONCOTARGETS AND THERAPY. - ISSN 1178-6930. - ELETTRONICO. - 12:(2019), pp. 9377-9384. [10.2147/OTT.S226257]
The hERG1 potassium channel behaves as prognostic factor in gastric dysplasia endoscopic samples
Lastraioli E.
;Romoli M. R.;Iorio J.;Lottini T.;Messerini L.;Arcangeli A.
2019
Abstract
hERG1 is aberrantly expressed in human GD samples and has an impact on both PFS and OS, hence representing a novel prognostic marker for progression of GD towards GC of the intestinal histotype. Once properly validated, hERG1 detection could be included in the clinical practice, during endoscopic surveillance protocols, for the management of GD at higher risk of progression, as already proposed for Barrett's oesophagus.
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