The authors prospectively studied 573 consecutive HCM patients in 3 centers (44 ± 17 years; 66% male) with New York Heart Association functional class I/II symptoms at study entry, including 249 in whom left ventricular outflow tract obstruction was absent both at rest and following physiological exercise (<30 mm Hg; nonobstructive HCM) and retrospectively assembled clinical follow-up data. HCM patients with nonobstructive disease appear to experience a relatively benign clinical course, associated with a low risk for advanced heart failure symptoms, other disease complications, and HCM-related mortality, and largely without the requirement for major treatment interventions. A small minority of nonobstructive HCM patients progress to heart transplant.

Contemporary Natural History and Management of Nonobstructive Hypertrophic Cardiomyopathy / Maron M.S.; Rowin E.J.; Olivotto I.; Casey S.A.; Arretini A.; Tomberli B.; Garberich R.F.; Link M.S.; Chan R.H.M.; Lesser J.R.; Maron B.J.. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - STAMPA. - 67:(2016), pp. 1399-1409. [10.1016/j.jacc.2016.01.023]

Contemporary Natural History and Management of Nonobstructive Hypertrophic Cardiomyopathy

Olivotto I.;Arretini A.;Tomberli B.;
2016

Abstract

The authors prospectively studied 573 consecutive HCM patients in 3 centers (44 ± 17 years; 66% male) with New York Heart Association functional class I/II symptoms at study entry, including 249 in whom left ventricular outflow tract obstruction was absent both at rest and following physiological exercise (<30 mm Hg; nonobstructive HCM) and retrospectively assembled clinical follow-up data. HCM patients with nonobstructive disease appear to experience a relatively benign clinical course, associated with a low risk for advanced heart failure symptoms, other disease complications, and HCM-related mortality, and largely without the requirement for major treatment interventions. A small minority of nonobstructive HCM patients progress to heart transplant.
2016
67
1399
1409
Maron M.S.; Rowin E.J.; Olivotto I.; Casey S.A.; Arretini A.; Tomberli B.; Garberich R.F.; Link M.S.; Chan R.H.M.; Lesser J.R.; Maron B.J.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1180780
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