Extensive late gadolinium enhancement (LGE) has been associated with adverse events in hypertrophic cardiomyopathy (HCM). It is unclear whether focal areas of LGE confined to the region of right ventricular (RV) insertion to ventricular septum is also associated with an adverse prognosis. In a large cohort of HCM patients, neither the presence nor extent of LGE, when confined to the RV insertion areas, was associated with an increased risk of adverse events. Furthermore, histopathology of post mortem HCM hearts demonstrated these areas to be composed of expanded extracellular space with areas of interstitial fibrosis, rather than replacement fibrosis and scarring.
Significance of Late Gadolinium Enhancement at Right Ventricular Attachment to Ventricular Septum in Patients with Hypertrophic Cardiomyopathy / Chan R.H.; Maron B.J.; Olivotto I.; Assenza G.E.; Haas T.S.; Lesser J.R.; Gruner C.; Crean A.M.; Rakowski H.; Rowin E.; Udelson J.; Lombardi M.; Tomberli B.; Spirito P.; Formisano F.; Marra M.P.; Biagini E.; Autore C.; Manning W.J.; Appelbaum E.; Roberts W.C.; Basso C.; Maron M.S.. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - STAMPA. - 116:(2015), pp. 436-441. [10.1016/j.amjcard.2015.04.060]
Significance of Late Gadolinium Enhancement at Right Ventricular Attachment to Ventricular Septum in Patients with Hypertrophic Cardiomyopathy
Olivotto I.;Tomberli B.;
2015
Abstract
Extensive late gadolinium enhancement (LGE) has been associated with adverse events in hypertrophic cardiomyopathy (HCM). It is unclear whether focal areas of LGE confined to the region of right ventricular (RV) insertion to ventricular septum is also associated with an adverse prognosis. In a large cohort of HCM patients, neither the presence nor extent of LGE, when confined to the RV insertion areas, was associated with an increased risk of adverse events. Furthermore, histopathology of post mortem HCM hearts demonstrated these areas to be composed of expanded extracellular space with areas of interstitial fibrosis, rather than replacement fibrosis and scarring.File | Dimensione | Formato | |
---|---|---|---|
junctional LGE JACC imaging submission.pdf
accesso aperto
Tipologia:
Altro
Licenza:
Open Access
Dimensione
1.18 MB
Formato
Adobe PDF
|
1.18 MB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.