G protein-coupled receptors (GPCRs) are the most common receptors on the surface of cardiomyocytes. GPCRs coupled to Gq play a central role in mediating the response of cardiac tissue to several hormones. Angiotensin-II (acting on the AT1 receptor), endothelin-1 (ETA receptor), and noradrenaline/adrenaline (alpha-adrenergic receptor) are the main hormones that share the intracellular signalling associated with Gq protein in the cardiomyocyte.
Cardiomyocyte-specific Gq signalling and arrhythmias: Novel insights from DREADD technology / Ferrantini C.; Coppini R.; Sacconi L.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - ELETTRONICO. - 115:(2019), pp. 992-994. [10.1093/cvr/cvz052]
Cardiomyocyte-specific Gq signalling and arrhythmias: Novel insights from DREADD technology
Ferrantini C.;Coppini R.;
2019
Abstract
G protein-coupled receptors (GPCRs) are the most common receptors on the surface of cardiomyocytes. GPCRs coupled to Gq play a central role in mediating the response of cardiac tissue to several hormones. Angiotensin-II (acting on the AT1 receptor), endothelin-1 (ETA receptor), and noradrenaline/adrenaline (alpha-adrenergic receptor) are the main hormones that share the intracellular signalling associated with Gq protein in the cardiomyocyte.
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