Relapsing oral and genital ulcers (OGUs) represent the stigmata of Behçet’s disease (BD) and may be very painful, affecting both quality of life and relationships. A wide number of topical and immunosuppressive drugs can be used to treat ulcers, but failures are commonly reported. The efficacy of the phosphodiesterase-4 inhibitor apremilast has been proven in OGUs of BD in two randomised clinical trials (RCTs), whereas only two case reports are available until now. We aimed at evaluating the real-world effectiveness of apremilast in BD patients with OGUs refractory to conventional and/or biological treatments
Real-world effectiveness of apremilast in multirefractory mucosal involvement of Behçet's disease / Lopalco G.; Venerito V.; Leccese P.; Emmi G.; Cantarini L.; Lascaro N.; DI Scala G.; Fabiani C.; Rigante D.; Iannone F.. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - ELETTRONICO. - 78:(2019), pp. 1736-1737. [10.1136/annrheumdis-2019-215437]
Real-world effectiveness of apremilast in multirefractory mucosal involvement of Behçet's disease
Emmi G.Membro del Collaboration Group
;DI Scala G.Membro del Collaboration Group
;Fabiani C.Membro del Collaboration Group
;
2019
Abstract
Relapsing oral and genital ulcers (OGUs) represent the stigmata of Behçet’s disease (BD) and may be very painful, affecting both quality of life and relationships. A wide number of topical and immunosuppressive drugs can be used to treat ulcers, but failures are commonly reported. The efficacy of the phosphodiesterase-4 inhibitor apremilast has been proven in OGUs of BD in two randomised clinical trials (RCTs), whereas only two case reports are available until now. We aimed at evaluating the real-world effectiveness of apremilast in BD patients with OGUs refractory to conventional and/or biological treatments
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