Increasing evidence shows an association between high lipoprotein(a) [Lp(a)] levels and atherothrombotic diseases. Lp(a) trait is largely controlled by kringle-IV type 2 (KIV-2) size polymorphism in LPA gene, encoding for apo(a). Environmental factors are considered to determinate minor phenotypic variability in Lp(a) levels. In the present study, we investigated the possible gene-environment interaction between KIV-2 polymorphism and Mediterranean diet adherence or fish weekly intake in determining Lp(a) levels. We evaluated Lp(a), KIV-2 polymorphism, fish intake and Mediterranean diet adherence in 452 subjects [median age (range) 66 (46-80)years] from Montignoso Heart and Lung Project (MEHLP) population. In subjects with high KIV-2 repeats number, influence of Mediterranean diet adherence in reducing Lp(a) levels was observed (p = 0.049). No significant difference in subjects with low KIV-2 repeats according to diet was found. Moreover, in high-KIV-2-repeat subjects, we observed a trend towards influence of fish intake on reducing Lp(a) levels (p = 0.186). At multivariate linear regression analysis, high adherence to Mediterranean diet remains a significant and independent determinant of lower Lp(a) levels (β = - 64.97, standard error = 26.55, p = 0.015). In conclusion, this study showed that only subjects with high KIV-2 repeats can take advantage to lower Lp(a) levels from correct nutritional habits and, in particular, from Mediterranean diet.

Genetic and nutritional factors determining circulating levels of lipoprotein(a): results of the "Montignoso Study" / Sticchi, Elena; Sereni, Alice; Gori, Anna Maria; Magi, Alberto; Della Latta, Daniele; Volta, Andrea; Murri, Alessandra; Jamagidze, Giuli; Chiappino, Dante; Abbate, Rosanna; Gensini, Gian Franco; Marcucci, Rossella; Sofi, Francesco; Giusti, Betti. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - STAMPA. - 15:(2020), pp. 1239-1245. [10.1007/s11739-020-02276-5]

Genetic and nutritional factors determining circulating levels of lipoprotein(a): results of the "Montignoso Study"

Sticchi, Elena
Writing – Original Draft Preparation
;
Sereni, Alice
Writing – Original Draft Preparation
;
Gori, Anna Maria
Investigation
;
Magi, Alberto
Investigation
;
Volta, Andrea
Formal Analysis
;
Abbate, Rosanna
Membro del Collaboration Group
;
Gensini, Gian Franco
Membro del Collaboration Group
;
Marcucci, Rossella
Writing – Review & Editing
;
Sofi, Francesco
Writing – Review & Editing
;
Giusti, Betti
Supervision
2020

Abstract

Increasing evidence shows an association between high lipoprotein(a) [Lp(a)] levels and atherothrombotic diseases. Lp(a) trait is largely controlled by kringle-IV type 2 (KIV-2) size polymorphism in LPA gene, encoding for apo(a). Environmental factors are considered to determinate minor phenotypic variability in Lp(a) levels. In the present study, we investigated the possible gene-environment interaction between KIV-2 polymorphism and Mediterranean diet adherence or fish weekly intake in determining Lp(a) levels. We evaluated Lp(a), KIV-2 polymorphism, fish intake and Mediterranean diet adherence in 452 subjects [median age (range) 66 (46-80)years] from Montignoso Heart and Lung Project (MEHLP) population. In subjects with high KIV-2 repeats number, influence of Mediterranean diet adherence in reducing Lp(a) levels was observed (p = 0.049). No significant difference in subjects with low KIV-2 repeats according to diet was found. Moreover, in high-KIV-2-repeat subjects, we observed a trend towards influence of fish intake on reducing Lp(a) levels (p = 0.186). At multivariate linear regression analysis, high adherence to Mediterranean diet remains a significant and independent determinant of lower Lp(a) levels (β = - 64.97, standard error = 26.55, p = 0.015). In conclusion, this study showed that only subjects with high KIV-2 repeats can take advantage to lower Lp(a) levels from correct nutritional habits and, in particular, from Mediterranean diet.
2020
15
1239
1245
Goal 3: Good health and well-being for people
Sticchi, Elena; Sereni, Alice; Gori, Anna Maria; Magi, Alberto; Della Latta, Daniele; Volta, Andrea; Murri, Alessandra; Jamagidze, Giuli; Chiappino, D...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1182562
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