The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.

Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC / Doghman-Bouguerr Ma, Finetti P, Durand N, Parise IZS, Sbiera S, Cantini G, Canu L, Hescot S, Figueiredo MOM, Komechen H, Sbiera I, Nesi G, Paci A, Al-Ghuzlan A, Birnbaum D, Baudin E, Luconi M, Fassnacht M, Figueiredo BC, Bertucci F, Lalli E. - In: CANCERS. - ISSN 2072-6694. - STAMPA. - 12:(2020), pp. 689-708. [10.3390/cancers12030689]

Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

Cantini G;Canu L;Nesi G;Luconi M;
2020

Abstract

The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.
2020
12
689
708
Goal 3: Good health and well-being for people
Doghman-Bouguerr Ma, Finetti P, Durand N, Parise IZS, Sbiera S, Cantini G, Canu L, Hescot S, Figueiredo MOM, Komechen H, Sbiera I, Nesi G, Paci A, Al-Ghuzlan A, Birnbaum D, Baudin E, Luconi M, Fassnacht M, Figueiredo BC, Bertucci F, Lalli E
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1186630
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