An increasing body of evidence suggests that dipeptidyl-peptidase 4 (DPP-4) inhibitors could play a role in the development of bullous pemphigoid. The knowledge regarding this association is based on case reports, pharmacovigilance database analyses, and observational studies. Data from randomized clinical trials are a relevant source of information on adverse events. Since no single trial has a sufficient power to assess the risk of very rare adverse events, such as pemphigoid, metanalyses of RCTs could be a useful tool for exploring this issue.

Bullous pemphigoid and dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized controlled trials / Silverii, Giovanni Antonio; Dicembrini, Ilaria; Nreu, Besmir; Montereggi, Chiara; Mannucci, Edoardo; Monami, Matteo. - In: ENDOCRINE. - ISSN 1355-008X. - ELETTRONICO. - (2020), pp. 0-0. [10.1007/s12020-020-02272-x]

Bullous pemphigoid and dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized controlled trials

Silverii, Giovanni Antonio;Dicembrini, Ilaria;Nreu, Besmir;Mannucci, Edoardo
;
Monami, Matteo
2020

Abstract

An increasing body of evidence suggests that dipeptidyl-peptidase 4 (DPP-4) inhibitors could play a role in the development of bullous pemphigoid. The knowledge regarding this association is based on case reports, pharmacovigilance database analyses, and observational studies. Data from randomized clinical trials are a relevant source of information on adverse events. Since no single trial has a sufficient power to assess the risk of very rare adverse events, such as pemphigoid, metanalyses of RCTs could be a useful tool for exploring this issue.
2020
0
0
Silverii, Giovanni Antonio; Dicembrini, Ilaria; Nreu, Besmir; Montereggi, Chiara; Mannucci, Edoardo; Monami, Matteo
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1189131
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