Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival

Muratori, F.; Mondanelli, N.; Pelagatti, L.; Frenos, F.; Matera, D.; Beltrami, G.; Innocenti, M.; Capanna, R.; Roselli, G.; Scoccianti, G.; Livi, L.; Greto, D.; Muntoni, C.; Baldi, G.; Tamburini, A.; Campanacci, D. A.

doi:10.1016/j.jor.2020.03.018

Objective: Authors review a series of 29 extra-skeletal Ewing Sarcoma (EES) Methods: They analyzed characteristics, prognostic factors and outcome of EES. Results: Authors report 60% Overall Survival (OS) and 56% of Event Free Survival (EFS) at 5 years. Better 5 years EFS was found in patients with localized disease (68.8%) compared to metastatic EES (33.3%) (p = 0.042). Radiotherapy + surgery offered the best local treatment (p=0.017). Volume (p = 0.032), Surgical margins (p = 0.01), metastatic disease (p = 0.0013) were a significant prognostic factor for OS at 5-yrs. Conclusion: Adequate margins and surgery+radiotherapy improve Overall Survival.

Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival / Muratori F., Mondanelli N., Pelagatti L., Frenos F., Matera D., Beltrami G., Innocenti M., Capanna R., Roselli G., Scoccianti G., Livi L., Greto D., Muntoni C., Baldi G., Tamburini A., Campanacci D.A.. - In: JOURNAL OF ORTHOPAEDICS. - ISSN 0972-978X. - STAMPA. - 21:(2020), pp. 236-239. [10.1016/j.jor.2020.03.018]