Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival

Muratori, F.; Mondanelli, N.; Pelagatti, L.; Frenos, F.; Matera, D.; Beltrami, G.; Innocenti, M.; Capanna, R.; Roselli, G.; Scoccianti, G.; Livi, L.; Greto, D.; Muntoni, C.; Baldi, G.; Tamburini, A.; Campanacci, D. A.

doi:10.1016/j.jor.2020.03.018

Objective: Authors review a series of 29 extra-skeletal Ewing Sarcoma (EES) Methods: They analyzed characteristics, prognostic factors and outcome of EES. Results: Authors report 60% Overall Survival (OS) and 56% of Event Free Survival (EFS) at 5 years. Better 5 years EFS was found in patients with localized disease (68.8%) compared to metastatic EES (33.3%) (p = 0.042). Radiotherapy + surgery offered the best local treatment (p=0.017). Volume (p = 0.032), Surgical margins (p = 0.01), metastatic disease (p = 0.0013) were a significant prognostic factor for OS at 5-yrs. Conclusion: Adequate margins and surgery+radiotherapy improve Overall Survival.

Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival / Muratori F.; Mondanelli N.; Pelagatti L.; Frenos F.; Matera D.; Beltrami G.; Innocenti M.; Capanna R.; Roselli G.; Scoccianti G.; Livi L.; Greto D.; Muntoni C.; Baldi G.; Tamburini A.; Campanacci D.A.. - In: JOURNAL OF ORTHOPAEDICS. - ISSN 0972-978X. - STAMPA. - 21:(2020), pp. 236-239. [10.1016/j.jor.2020.03.018]