Objectives: To evaluate the association of magnetic resonance diffusion-weighted imaging (DwI) and dynamic contrast-enhanced perfusion-weighted imaging (DCE-PwI) with a temporal resolution of 5 s, wash-in < 120 s, and wash-out ratio > 30% in the evaluation of salivary glands neoplasms. Methods: DwI and DCE-PwI of 92 salivary glands neoplasms were assessed. The apparent diffusion coefficient (ADC) was calculated by drawing three regions of interest with an average area of 0.30–0.40 cm2 on three contiguous axial sections. The time/intensity curve was generated from DCE-PwI images by drawing a region of interest that included at least 50% of the largest lesion section. Vessels, calcifications, and necrotic/haemorrhagic or cystic areas within solid components were excluded. The association of ADC ≥ 1.4 × 10−3 mm2/s with type A curves (progressive wash-in) and ADC 0.9–1.4 × 10−3 mm2/s with type C curves (rapid wash-in/slow wash-out) were tested as parameters of benignity and malignancy, respectively. Type B curve (rapid wash-in/rapid wash-out) was not used as a reference parameter. Results: ADC ≥ 1.4 × 10−3 mm2/s and type A curves were observed only in benign neoplasms. ADC of 0.9–1.4 × 10−3 mm2/s and type C curves association showed specificity of 94.9% and positive predictive value of 81.8% for epithelial malignancies. The association of ADC < 0.9 × 10−3 mm2/s with type B and C curves showed diagnostic accuracy of 94.6% and 100% for Warthin tumour and lymphoma, respectively. Conclusions: ADC ≥ 1.4 × 10−3 mm2/s and type A curves association was indicative of benignity. Lymphomas exhibited ADC < 0.7 × 10−3 mm2/s and type C curves. The association of ADC < 0.9 × 10−3 mm2/s and type B and C curves had accuracy 94.6% and 88.5% for Warthin tumour and epithelial malignancies, respectively.

The role of diffusion-weighted and dynamic contrast enhancement perfusion-weighted imaging in the evaluation of salivary glands neoplasms / Pietragalla M.; Nardi C.; Bonasera L.; Mungai F.; Taverna C.; Novelli L.; De Renzis A.G.D.; Calistri L.; Tomei M.; Occhipinti M.; Colagrande S.. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - ELETTRONICO. - 125:(2020), pp. 851-863. [10.1007/s11547-020-01182-2]

The role of diffusion-weighted and dynamic contrast enhancement perfusion-weighted imaging in the evaluation of salivary glands neoplasms

Pietragalla M.
;
Nardi C.;Bonasera L.;Mungai F.;Taverna C.;Calistri L.;Occhipinti M.;Colagrande S.
2020

Abstract

Objectives: To evaluate the association of magnetic resonance diffusion-weighted imaging (DwI) and dynamic contrast-enhanced perfusion-weighted imaging (DCE-PwI) with a temporal resolution of 5 s, wash-in < 120 s, and wash-out ratio > 30% in the evaluation of salivary glands neoplasms. Methods: DwI and DCE-PwI of 92 salivary glands neoplasms were assessed. The apparent diffusion coefficient (ADC) was calculated by drawing three regions of interest with an average area of 0.30–0.40 cm2 on three contiguous axial sections. The time/intensity curve was generated from DCE-PwI images by drawing a region of interest that included at least 50% of the largest lesion section. Vessels, calcifications, and necrotic/haemorrhagic or cystic areas within solid components were excluded. The association of ADC ≥ 1.4 × 10−3 mm2/s with type A curves (progressive wash-in) and ADC 0.9–1.4 × 10−3 mm2/s with type C curves (rapid wash-in/slow wash-out) were tested as parameters of benignity and malignancy, respectively. Type B curve (rapid wash-in/rapid wash-out) was not used as a reference parameter. Results: ADC ≥ 1.4 × 10−3 mm2/s and type A curves were observed only in benign neoplasms. ADC of 0.9–1.4 × 10−3 mm2/s and type C curves association showed specificity of 94.9% and positive predictive value of 81.8% for epithelial malignancies. The association of ADC < 0.9 × 10−3 mm2/s with type B and C curves showed diagnostic accuracy of 94.6% and 100% for Warthin tumour and lymphoma, respectively. Conclusions: ADC ≥ 1.4 × 10−3 mm2/s and type A curves association was indicative of benignity. Lymphomas exhibited ADC < 0.7 × 10−3 mm2/s and type C curves. The association of ADC < 0.9 × 10−3 mm2/s and type B and C curves had accuracy 94.6% and 88.5% for Warthin tumour and epithelial malignancies, respectively.
125
851
863
Goal 3: Good health and well-being
Pietragalla M.; Nardi C.; Bonasera L.; Mungai F.; Taverna C.; Novelli L.; De Renzis A.G.D.; Calistri L.; Tomei M.; Occhipinti M.; Colagrande S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1190579
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