The reductive amination (RA) reaction plays a pivotal role in the synthesis of new C–N bonds, due to the availability of many different and low-cost reagents and their operational simplicity. The introduction in a compound of a nitrogen-containing moiety that can be reduced to an amine in the reaction medium allows to perform cascade reactions which further expand this method. The application of the intramolecular version of the RA to carbohydrates allows the synthesis of polyhydroxypiperidine iminosugars, which are among the most challenging and fascinating glycomimetics for a synthetic chemist. This minireview focuses on the use of RA and of the double reductive amination (DRA) reaction in the key ring-closing step en route to the synthesis of these compounds.

Reductive Amination Routes in the Synthesis of Piperidine IminoSugars / Francesca Clemente, Camilla Matassini, Francesca Cardona. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - STAMPA. - 2020:(2020), pp. 4447-4462. [10.1002/ejoc.201901840]

Reductive Amination Routes in the Synthesis of Piperidine IminoSugars

Francesca Clemente
Membro del Collaboration Group
;
Camilla Matassini
Membro del Collaboration Group
;
Francesca Cardona
2020

Abstract

The reductive amination (RA) reaction plays a pivotal role in the synthesis of new C–N bonds, due to the availability of many different and low-cost reagents and their operational simplicity. The introduction in a compound of a nitrogen-containing moiety that can be reduced to an amine in the reaction medium allows to perform cascade reactions which further expand this method. The application of the intramolecular version of the RA to carbohydrates allows the synthesis of polyhydroxypiperidine iminosugars, which are among the most challenging and fascinating glycomimetics for a synthetic chemist. This minireview focuses on the use of RA and of the double reductive amination (DRA) reaction in the key ring-closing step en route to the synthesis of these compounds.
2020
2020
4447
4462
Goal 9: Industry, Innovation, and Infrastructure
Francesca Clemente, Camilla Matassini, Francesca Cardona
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1191715
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