Bipolar disorder is characterized by mood swings alternating from depression to (hypo-)manic, including mixed states. Currently, patient mood is typically assessed by clinician-administered rating scales and subjective evaluations exclusively. To overcome this limitation, here we propose a methodology predicting mood changes using heartbeat nonlinear dynamics. Such changes are intended as transitioning between euthymic state (EUT), i.e., the good affective balance, and non-euthymic state. We analyzed Heart Rate Variability (HRV) series gathered from four bipolar patients involved in the European project PSYCHE, undergoing 24h ECG monitoring through textile-based wearable systems. Each patient was monitored twice a week, for 14 weeks, being able to perform normal (unstructured) activities. From each acquisition, the longest artifact-free segment of heartbeat dynamics was selected for further analyses. Sub-segments of 5 minutes of this segment were used to estimate trends of HRV linear and nonlinear dynamics. Considering data from a current observation at day t0, and past observations at days (t-1, t-2,⋯ ,), personalized prediction accuracies in forecasting a mood state (EUT/non-EUT) at day t+1 were 74.18% on average. This approach is intended as a proof of concept of the possibility of predicting mood states in bipolar patients through heartbeat nonlinear dynamics exclusively.
Predicting mood changes in bipolar disorder through heartbeat nonlinear dynamics: A preliminary study / VALENZA, GAETANO; NARDELLI, MIMMA; LANATA', ANTONIO; Gentili, Claudio; Bertschy, Gilles; SCILINGO, ENZO PASQUALE. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-8861. - ELETTRONICO. - 42:(2015), pp. 801-804. (Intervento presentato al convegno 42nd Computing in Cardiology Conference, CinC 2015 tenutosi a Nice nel 06/09/2015-09/09/2015) [10.1109/CIC.2015.7411032].
Predicting mood changes in bipolar disorder through heartbeat nonlinear dynamics: A preliminary study
LANATA', ANTONIO;
2015
Abstract
Bipolar disorder is characterized by mood swings alternating from depression to (hypo-)manic, including mixed states. Currently, patient mood is typically assessed by clinician-administered rating scales and subjective evaluations exclusively. To overcome this limitation, here we propose a methodology predicting mood changes using heartbeat nonlinear dynamics. Such changes are intended as transitioning between euthymic state (EUT), i.e., the good affective balance, and non-euthymic state. We analyzed Heart Rate Variability (HRV) series gathered from four bipolar patients involved in the European project PSYCHE, undergoing 24h ECG monitoring through textile-based wearable systems. Each patient was monitored twice a week, for 14 weeks, being able to perform normal (unstructured) activities. From each acquisition, the longest artifact-free segment of heartbeat dynamics was selected for further analyses. Sub-segments of 5 minutes of this segment were used to estimate trends of HRV linear and nonlinear dynamics. Considering data from a current observation at day t0, and past observations at days (t-1, t-2,⋯ ,), personalized prediction accuracies in forecasting a mood state (EUT/non-EUT) at day t+1 were 74.18% on average. This approach is intended as a proof of concept of the possibility of predicting mood states in bipolar patients through heartbeat nonlinear dynamics exclusively.File | Dimensione | Formato | |
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