There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies. (C) 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Lesional and non-lesional epilepsies: A blurring genetic boundary / Guerrini R, Parrini E, Esposito A, Fassio A, Conti V. - In: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. - ISSN 1090-3798. - ELETTRONICO. - 24:(2020), pp. 24-29. [10.1016/j.ejpn.2019.12.013]
Lesional and non-lesional epilepsies: A blurring genetic boundary.
Guerrini R;Conti V
2020
Abstract
There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies. (C) 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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