Existing immunological and microbiological TB tests have suboptimal sensitivity in children with TBM, with each test producing false-negative results in a substantial proportion of patients. Combining immune-based tests with CSF culture and CSF PCR results in considerably higher positive diagnostic yields, and should therefore be standard clinical practice in high-resource settings.
Performance of Immune-Based and Microbiological Tests in Children With TB Meningitis in Europe - A Multi-Center Paediatric Tuberculosis Network European Trials Group (Ptbnet) Study / Galli Luisa. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - ELETTRONICO. - (2020), pp. 1902004-1902004. [10.1183/13993003.02004-2019]
Performance of Immune-Based and Microbiological Tests in Children With TB Meningitis in Europe - A Multi-Center Paediatric Tuberculosis Network European Trials Group (Ptbnet) Study
Galli Luisa
2020
Abstract
Existing immunological and microbiological TB tests have suboptimal sensitivity in children with TBM, with each test producing false-negative results in a substantial proportion of patients. Combining immune-based tests with CSF culture and CSF PCR results in considerably higher positive diagnostic yields, and should therefore be standard clinical practice in high-resource settings.File | Dimensione | Formato | |
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