In this review we present the instrumental and theoretical developments for functional diffuse reflectance spectroscopy at small source-detector distances. We proposed the possibility to perform photon migration measurements at null or small inter-fiber distances demonstrating the improvement of this novel approach in terms of achievable contrast, spatial resolution and number of detected photons. We developed a novel system to perform time-resolved diffuse reflectance measurement at small source detector separation based on a single photon avalanche photodiode (SPAD) operated in fast time gated mode and a broadband fiber laser. By means of time gating it is possible to detect longer lived photons neglecting initial ones. We show results both on homogeneous and inhomogeneous tissue phantoms demonstrating a dynamic range of 7 orders of magnitude and a temporal range of 6 nanoseconds. Furthermore, this approach proved valuable to detect brain activity. © 2010 Copyright SPIE - The International Society for Optical Engineering.

Functional diffuse reflectance spectroscopy at small source-detector distances based on fast-gated single-photon avalanche diodes / Contini D.; Pifferi A.; Spinelli L.; Torricelli A.; Cubeddu R.; Martelli F.; Zaccanti G.; Dalla Mora A.; Tosi A.; Zappa F.; Cova S.. - ELETTRONICO. - 7681:(2010), pp. 768102-1-768102-8. ((Intervento presentato al convegno Advanced Photon Counting Techniques IV tenutosi a Orlando, FL, usa nel 2010 [10.1117/12.852557].

Functional diffuse reflectance spectroscopy at small source-detector distances based on fast-gated single-photon avalanche diodes

Martelli F.
Membro del Collaboration Group
;
Zaccanti G.;
2010

Abstract

In this review we present the instrumental and theoretical developments for functional diffuse reflectance spectroscopy at small source-detector distances. We proposed the possibility to perform photon migration measurements at null or small inter-fiber distances demonstrating the improvement of this novel approach in terms of achievable contrast, spatial resolution and number of detected photons. We developed a novel system to perform time-resolved diffuse reflectance measurement at small source detector separation based on a single photon avalanche photodiode (SPAD) operated in fast time gated mode and a broadband fiber laser. By means of time gating it is possible to detect longer lived photons neglecting initial ones. We show results both on homogeneous and inhomogeneous tissue phantoms demonstrating a dynamic range of 7 orders of magnitude and a temporal range of 6 nanoseconds. Furthermore, this approach proved valuable to detect brain activity. © 2010 Copyright SPIE - The International Society for Optical Engineering.
Proceedings of SPIE - The International Society for Optical Engineering
Advanced Photon Counting Techniques IV
Orlando, FL, usa
2010
Goal 3: Good health and well-being
Contini D.; Pifferi A.; Spinelli L.; Torricelli A.; Cubeddu R.; Martelli F.; Zaccanti G.; Dalla Mora A.; Tosi A.; Zappa F.; Cova S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1194525
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