We describe 10 children with Alagille syndrome and inflammatory arthritis. In our centers, the prevalence of chronic arthritis in patients with Alagille syndrome is approximately 50 times higher compared with the general population. Arthritis was refractory to most treatment. Patients with Alagille syndrome should routinely be screened for musculoskeletal symptoms.
Alagille Syndrome and Chronic Arthritis: An International Case Series / Ferrara G.; Giani T.; Lieberman S.M.; Kremer C.; Hong S.; Indolfi G.; Schulert G.; Cron R.Q.; Mannion M.L.; Lapidus S.; Armbrust W.; Gonzales E.; Jacquemin E.; Kone-Paut I.; Cimaz R.. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - ELETTRONICO. - 218:(2020), pp. 228-230.e1. [10.1016/j.jpeds.2019.10.042]
Alagille Syndrome and Chronic Arthritis: An International Case Series
Ferrara G.;Giani T.;Indolfi G.;Cimaz R.
2020
Abstract
We describe 10 children with Alagille syndrome and inflammatory arthritis. In our centers, the prevalence of chronic arthritis in patients with Alagille syndrome is approximately 50 times higher compared with the general population. Arthritis was refractory to most treatment. Patients with Alagille syndrome should routinely be screened for musculoskeletal symptoms.
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