Prolonged outbreak of New Delhi metallo-betalactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE), Tuscany, Italy, 2018 to 2019

Tavoschi, L.; Forni, S.; Porretta, A.; Righi, L.; Pieralli, F.; Menichetti, F.; Falcone, M.; Gemignani, G.; Sani, S.; Vivani, P.; Bellandi, T.; Tacconi, D.; Turini, L.; Toccafondi, G.; Privitera, G.; Lopalco, P.; Baggiani, A.; Gemmi, F.; Luchini, G.; Petrillo, M.; Roti, L.; Pezzotti, P.; Pantosti, A.; Iannazzo, S.; Mechi, M.; Rossolini, G. M.

doi:10.2807/1560-7917.ES.2020.25.6.2000085

In Tuscany, Italy, New Delhi metallo-beta-lactamaseproducing carbapenem-resistant Enterobacterales (NDM-CRE) have increased since November 2018. Between November 2018 and October 2019, 1,645 samples were NDM-CRE-positive: 1,270 (77.2%) cases of intestinal carriage, 129 (7.8%) bloodstream infections and 246 (14.9%) infections/colonisations at other sites. Klebsiella pneumoniae were prevalent (1,495; 90.9%), with ST147/NDM-1 the dominant clone. Delayed outbreak identification and response resulted in sustained NDM-CRE transmission in the North-West area of Tuscany, but successfully contained spread within the region.

Prolonged outbreak of New Delhi metallo-betalactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE), Tuscany, Italy, 2018 to 2019 / Tavoschi L., Forni S., Porretta A., Righi L., Pieralli F., Menichetti F., Falcone M., Gemignani G., Sani S., Vivani P., Bellandi T., Tacconi D., Turini L., Toccafondi G., Privitera G., Lopalco P., Baggiani A., Gemmi F., Luchini G., Petrillo M., et al.. - In: EUROSURVEILLANCE. - ISSN 1025-496X. - ELETTRONICO. - 25:(2020), pp. 13-19. [10.2807/1560-7917.ES.2020.25.6.2000085]