Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak / Falcone M.; Tiseo G.; Antonelli A.; Giordano C.; Di Pilato V.; Bertolucci P.; Parisio E.M.; Leonildi A.; Aiezza N.; Baccani I.; Tagliaferri E.; Righi L.; Forni S.; Sani S.; Mechi M.T.; Pieralli F.; Barnini S.; Rossolini G.M.; Menichetti F.. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - ELETTRONICO. - 7:(2020), pp. ofaa011-ofaa011. [10.1093/ofid/ofaa011]
Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak
Antonelli A.;Di Pilato V.;Aiezza N.;Baccani I.;Rossolini G. M.;
2020
Abstract
Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
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