Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak / Falcone M., Tiseo G., Antonelli A., Giordano C., Di Pilato V., Bertolucci P., Parisio E.M., Leonildi A., Aiezza N., Baccani I., Tagliaferri E., Righi L., Forni S., Sani S., Mechi M.T., Pieralli F., Barnini S., Rossolini G.M., Menichetti F.. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - ELETTRONICO. - 7:(2020), pp. ofaa011-ofaa011. [10.1093/ofid/ofaa011]
Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak
Antonelli A.;Di Pilato V.;Aiezza N.;Baccani I.;Rossolini G. M.;
2020
Abstract
Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
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