To identify clinical variables capable of predicting long-term treatment duration of TNF-α inhibition in patients with Behçet’s disease (BD)-related uveitis. Demographic, clinical, and therapeutic data were retrospectively collected from BD patients treated with the tumor necrosis factor (TNF)-α blockers infliximab and adalimumab. Patients still continuing TNF-α inhibitors at 48-month follow-up visits were classified as long-term responders and were statistically compared to patients discontinuing treatment before the 48-month visit. Forty-five patients (75 eyes) were enrolled. Thirty-two patients continued anti-TNF-α treatment for more than 48 months; 13 patients discontinued the treatment after a mean time of 12.3 ± 10.44 months due to lack (61.5%) or loss (38.5%) of efficacy. Baseline value of BD current activity form was the only variable discriminating long- and short-term responsive patients (p = 0.048, OR = 0.656, C.I. 95% 0.433–0.996). Disease activity levels at the start of treatment predict duration of response to monoclonal TNF antagonists in ocular BD.
Predictors of Sustained Clinical Response in Patients With Behçet's Disease-Related Uveitis Treated With Infliximab and Adalimumab / Fabiani C.; Vitale A.; Rigante D.; Emmi G.; Lopalco G.; Sota J.; Vannozzi L.; di Scala G.; Guerriero S.; Orlando I.; Franceschini R.; Capozzoli M.; Frediani B.; Galeazzi M.; Iannone F.; Tosi G.M.; Cantarini L.. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - ELETTRONICO. - 37:(2018), pp. 1715-1720. [10.1007/s10067-018-4092-4]
Predictors of Sustained Clinical Response in Patients With Behçet's Disease-Related Uveitis Treated With Infliximab and Adalimumab
Fabiani C.;Emmi G.;Vannozzi L.;di Scala G.;Orlando I.;Galeazzi M.;
2018
Abstract
To identify clinical variables capable of predicting long-term treatment duration of TNF-α inhibition in patients with Behçet’s disease (BD)-related uveitis. Demographic, clinical, and therapeutic data were retrospectively collected from BD patients treated with the tumor necrosis factor (TNF)-α blockers infliximab and adalimumab. Patients still continuing TNF-α inhibitors at 48-month follow-up visits were classified as long-term responders and were statistically compared to patients discontinuing treatment before the 48-month visit. Forty-five patients (75 eyes) were enrolled. Thirty-two patients continued anti-TNF-α treatment for more than 48 months; 13 patients discontinued the treatment after a mean time of 12.3 ± 10.44 months due to lack (61.5%) or loss (38.5%) of efficacy. Baseline value of BD current activity form was the only variable discriminating long- and short-term responsive patients (p = 0.048, OR = 0.656, C.I. 95% 0.433–0.996). Disease activity levels at the start of treatment predict duration of response to monoclonal TNF antagonists in ocular BD.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.