Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease included in the spectrum of ANCA-associated vasculitis, although ANCA (usually anti-MPO, MPO ANCA) are positive in only ∼40% of patients. EGPA almost invariably shows eosinophilia, asthma and rhinosinusitis. Other manifestations tend to segregate in two main subsets defined on ANCA status, with ANCA-positive patients more commonly showing vasculitic manifestations [1]. The genetic background of EGPA is complex: ANCA-positive EGPA is associated with HLA-DQ (similar to MPO ANCA-associated vasculitis), while the ANCA-negative subgroup...

FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis / Alberici, Federico; Bonatti, Francesco; Adorni, Alessia; Daminelli, Giulia; Sinico, Renato A; Gregorini, Gina; Marvisi, Chiara; Fenaroli, Paride; Peyronel, Francesco; Maritati, Federica; Palmisano, Alessandra; Urban, Maria Letizia; Percesepe, Antonio; Emmi, Giacomo; Martorana, Davide; Vaglio, Augusto. - In: RHEUMATOLOGY. - ISSN 1462-0324. - ELETTRONICO. - (2020), pp. 1-10. [10.1093/rheumatology/keaa134]

FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis

Urban, Maria Letizia;Emmi, Giacomo;Vaglio, Augusto
2020

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease included in the spectrum of ANCA-associated vasculitis, although ANCA (usually anti-MPO, MPO ANCA) are positive in only ∼40% of patients. EGPA almost invariably shows eosinophilia, asthma and rhinosinusitis. Other manifestations tend to segregate in two main subsets defined on ANCA status, with ANCA-positive patients more commonly showing vasculitic manifestations [1]. The genetic background of EGPA is complex: ANCA-positive EGPA is associated with HLA-DQ (similar to MPO ANCA-associated vasculitis), while the ANCA-negative subgroup...
2020
1
10
Goal 3: Good health and well-being for people
Alberici, Federico; Bonatti, Francesco; Adorni, Alessia; Daminelli, Giulia; Sinico, Renato A; Gregorini, Gina; Marvisi, Chiara; Fenaroli, Paride; Peyr...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1197625
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