Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease included in the spectrum of ANCA-associated vasculitis, although ANCA (usually anti-MPO, MPO ANCA) are positive in only ∼40% of patients. EGPA almost invariably shows eosinophilia, asthma and rhinosinusitis. Other manifestations tend to segregate in two main subsets defined on ANCA status, with ANCA-positive patients more commonly showing vasculitic manifestations [1]. The genetic background of EGPA is complex: ANCA-positive EGPA is associated with HLA-DQ (similar to MPO ANCA-associated vasculitis), while the ANCA-negative subgroup...
FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis / Alberici, F., Bonatti, F., Adorni, A., Daminelli, G., Sinico, R.A., Gregorini, G., Marvisi, C., Fenaroli, P., Peyronel, F., Maritati, F., Palmisano, A., Urban, M.L., Percesepe, A., Emmi, G., Martorana, D., Vaglio, A.. - In: RHEUMATOLOGY. - ISSN 1462-0324. - ELETTRONICO. - (2020), pp. 1-10. [10.1093/rheumatology/keaa134]
FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis
Urban, Maria Letizia;Emmi, Giacomo;Vaglio, Augusto
2020
Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease included in the spectrum of ANCA-associated vasculitis, although ANCA (usually anti-MPO, MPO ANCA) are positive in only ∼40% of patients. EGPA almost invariably shows eosinophilia, asthma and rhinosinusitis. Other manifestations tend to segregate in two main subsets defined on ANCA status, with ANCA-positive patients more commonly showing vasculitic manifestations [1]. The genetic background of EGPA is complex: ANCA-positive EGPA is associated with HLA-DQ (similar to MPO ANCA-associated vasculitis), while the ANCA-negative subgroup...
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