Low testosterone (T) in Klinefelter's syndrome (KS) can contribute to typical features of the syndrome such as reduced bone mineral density, obesity, metabolic disturbances and increased cardiovascular risk. The aim of the present study is to review and meta-analyze all available information regarding possible differences in metabolic and bone homeostasis profile between T treated (TRT) or untreated KS and age-matched controls.
Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis / Pizzocaro, A; Vena, W; Condorelli, R; Radicioni, A; Rastrelli, G; Pasquali, D; Selice, R; Ferlin, A; Foresta, C; Jannini, E A; Maggi, M; Lenzi, A; Pivonello, R; Isidori, A M; Garolla, A; Francavilla, S; Corona, G. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - STAMPA. - 43:(2020), pp. 1675-1687. [10.1007/s40618-020-01299-1]
Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis
Rastrelli, G;Maggi, M;
2020
Abstract
Low testosterone (T) in Klinefelter's syndrome (KS) can contribute to typical features of the syndrome such as reduced bone mineral density, obesity, metabolic disturbances and increased cardiovascular risk. The aim of the present study is to review and meta-analyze all available information regarding possible differences in metabolic and bone homeostasis profile between T treated (TRT) or untreated KS and age-matched controls.
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