Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa.
A novel colistin adjuvant identified by virtual screening for ArnT inhibitors / Ghirga, Francesca; Stefanelli, Roberta; Cavinato, Luca; Lo Sciuto, Alessandra; Corradi, Silvia; Quaglio, Deborah; Calcaterra, Andrea; Casciaro, Bruno; Loffredo, Maria Rosa; Cappiello, Floriana; Morelli, Patrizia; Antonelli, Alberto; Rossolini, Gian Maria; Mangoni, Marialuisa; Mancone, Carmine; Botta, Bruno; Mori, Mattia; Ascenzioni, Fiorentina; Imperi, Francesco. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - (2020), pp. 0-0. [10.1093/jac/dkaa200]
A novel colistin adjuvant identified by virtual screening for ArnT inhibitors
Corradi, Silvia;Antonelli, Alberto;Rossolini, Gian Maria;Mori, Mattia;Imperi, Francesco
2020
Abstract
Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa.
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