Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa.
A novel colistin adjuvant identified by virtual screening for ArnT inhibitors / Ghirga, F., Stefanelli, R., Cavinato, L., Lo Sciuto, A., Corradi, S., Quaglio, D., Calcaterra, A., Casciaro, B., Loffredo, M.R., Cappiello, F., Morelli, P., Antonelli, A., Rossolini, G.M., Mangoni, M., Mancone, C., Botta, B., Mori, M., Ascenzioni, F., Imperi, F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - (2020), pp. 0-0. [10.1093/jac/dkaa200]
A novel colistin adjuvant identified by virtual screening for ArnT inhibitors
Corradi, Silvia;Antonelli, Alberto;Rossolini, Gian Maria;Mori, Mattia;Imperi, Francesco
2020
Abstract
Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa.
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