.Quantitative analysis of biomedical images, referred to as radiomics, is emerging as a promising approach to facilitate clinical decisions and improve patient stratification. The typical radiomic workflow includes image acquisition, segmentation, feature extraction, and analysis of high-dimensional datasets. While procedures for primary radiomic analyses have been established in recent years, processing the resulting radiomic datasets remains a challenge due to the lack of specific tools for doing so. Here we present RadAR (Radiomics Analysis with R), a new software to perform comprehensive analysis of radiomic features. RadAR allows users to process radiomic datasets in their entirety, from data import to feature processing and visualization, and implements multiple statistical methods for analysis of these data. We used RadAR to analyze the radiomic profiles of more than 850 patients with cancer from publicly available datasets and showed that it was able to recapitulate expected results. These results demonstrate RadAR as a reliable and valuable tool for the radiomics community. Significance: A new computational tool performs comprehensive analysis of high-dimensional radiomic datasets, recapitulating expected results in the analysis of radiomic profiles of >850 patients with cancer from independent datasets.

Comprehensive analysis of radiomic datasets by RadAR / Matteo Benelli, Andrea Barucci, Nicola zoppetti, Silvia Calusi, Laura Redapi, Giuseppe Della Gala, Stefano Piffer, Luca Bernardi, Franco Fusi, Stefania Pallotta. - In: CANCER RESEARCH. - ISSN 1538-7445. - STAMPA. - 80:(2020), pp. 3170-3174. [10.1158/0008-5472.CAN-20-0332]

Comprehensive analysis of radiomic datasets by RadAR

Matteo Benelli
;
Andrea Barucci;Silvia Calusi;Laura Redapi;Giuseppe Della Gala;Stefano Piffer;Luca Bernardi;Franco Fusi;Stefania Pallotta
2020

Abstract

.Quantitative analysis of biomedical images, referred to as radiomics, is emerging as a promising approach to facilitate clinical decisions and improve patient stratification. The typical radiomic workflow includes image acquisition, segmentation, feature extraction, and analysis of high-dimensional datasets. While procedures for primary radiomic analyses have been established in recent years, processing the resulting radiomic datasets remains a challenge due to the lack of specific tools for doing so. Here we present RadAR (Radiomics Analysis with R), a new software to perform comprehensive analysis of radiomic features. RadAR allows users to process radiomic datasets in their entirety, from data import to feature processing and visualization, and implements multiple statistical methods for analysis of these data. We used RadAR to analyze the radiomic profiles of more than 850 patients with cancer from publicly available datasets and showed that it was able to recapitulate expected results. These results demonstrate RadAR as a reliable and valuable tool for the radiomics community. Significance: A new computational tool performs comprehensive analysis of high-dimensional radiomic datasets, recapitulating expected results in the analysis of radiomic profiles of >850 patients with cancer from independent datasets.
2020
80
3170
3174
Goal 3: Good health and well-being for people
Matteo Benelli, Andrea Barucci, Nicola zoppetti, Silvia Calusi, Laura Redapi, Giuseppe Della Gala, Stefano Piffer, Luca Bernardi, Franco Fusi, Stefani...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1203535
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