SM 21 is a 2-phenylpropionic acid ester, structurally related to atropine, that produces a central antinociceptive and antiamnesic effect in mice and rats. These activities are exerted without impairing motor coordination and without producing typical cholinergic symptomatology. SM 2 1 is also able to amplify the evoked contractions of smooth and striated muscle. A potentiation of endogenous cholinergic activity, by enhancing ACh extracellular levels, can be considered responsible for the action of SM 21 on both the central and peripheral nervous system. However, at this point the exact mechanism by which ACh levels are increased is not entirely elucidated.

3-ALFA-TROPANYL 2-(4-Cl-PHENOXY)BUTIRATE (SM21): A REVIEW OF THE PHARMACOLOGICAL PROFILE OF A NOVEL ENHANCER OF CHOLINERGIC TRANSMISSION.

GHELARDINI, CARLA;GALEOTTI, NICOLETTA;GUALTIERI, FULVIO;SCAPECCHI, SERENA;BARTOLINI, ALESSANDRO
1997

Abstract

SM 21 is a 2-phenylpropionic acid ester, structurally related to atropine, that produces a central antinociceptive and antiamnesic effect in mice and rats. These activities are exerted without impairing motor coordination and without producing typical cholinergic symptomatology. SM 2 1 is also able to amplify the evoked contractions of smooth and striated muscle. A potentiation of endogenous cholinergic activity, by enhancing ACh extracellular levels, can be considered responsible for the action of SM 21 on both the central and peripheral nervous system. However, at this point the exact mechanism by which ACh levels are increased is not entirely elucidated.
3
346
362
C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; S. SCAPECCHI; A. BARTOLINI
File in questo prodotto:
File Dimensione Formato  
19.SM21 CNS Drug Rev.pdf

accesso aperto

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Open Access
Dimensione 849.42 kB
Formato Adobe PDF
849.42 kB Adobe PDF Visualizza/Apri

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1207
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 12
social impact