Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment. Considering the relevance of the immune infiltrate in supporting melanoma progression, we also focus on the role of PTPs in modulating immune cell activity, identifying interesting therapeutic options that may support the currently applied immunomodulating approaches. Collectively, this information highlights the value of going further in the development of new strategies targeting oncogenic PTPs to improve the efficacy of melanoma treatment.

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment / Elisa Pardella, Erica Pranzini, Angela Leo, Maria Letizia Taddei, Paolo Paoli, Giovanni Raugei. - In: CANCERS. - ISSN 2072-6694. - ELETTRONICO. - 12:(2020), pp. 2799-2826. [10.3390/cancers12102799]

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

Erica Pranzini;Angela Leo;Maria Letizia Taddei;Paolo Paoli
;
Giovanni Raugei
2020

Abstract

Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment. Considering the relevance of the immune infiltrate in supporting melanoma progression, we also focus on the role of PTPs in modulating immune cell activity, identifying interesting therapeutic options that may support the currently applied immunomodulating approaches. Collectively, this information highlights the value of going further in the development of new strategies targeting oncogenic PTPs to improve the efficacy of melanoma treatment.
2020
12
2799
2826
Goal 3: Good health and well-being for people
Elisa Pardella, Erica Pranzini, Angela Leo, Maria Letizia Taddei, Paolo Paoli, Giovanni Raugei
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1208786
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