BCL2 was methylated in 64% of bladder TCC patients, hTERT in 44% and DAPK in 25%, with an overall sensitivity included patients with potentially false positive results using other urinary markers. DNA methylation was correlated with tumor grade both as methylation degree and number of methylated genes. There was a patient age, while there was a weak correlation between methylation degree in urine sediment and freshly-processed tumor biopsies.
Quantitative methylation-specific PCR of DAPK, BCL2 and hTERT genes in urine sediments of patients with bladder TCC / Cesare Selli, Jitka Kuncova, Gianluca Giannarini, Donata Villari, Serena Vinci, Claudio Orlando. - In: THE JOURNAL OF UROLOGY. - ISSN 0022-5347. - ELETTRONICO. - 179:(2008), pp. 266-266. [10.1016/S0022-5347(08)60771-5]
Quantitative methylation-specific PCR of DAPK, BCL2 and hTERT genes in urine sediments of patients with bladder TCC
Cesare Selli;Donata Villari;Serena Vinci;Claudio Orlando
2008
Abstract
BCL2 was methylated in 64% of bladder TCC patients, hTERT in 44% and DAPK in 25%, with an overall sensitivity included patients with potentially false positive results using other urinary markers. DNA methylation was correlated with tumor grade both as methylation degree and number of methylated genes. There was a patient age, while there was a weak correlation between methylation degree in urine sediment and freshly-processed tumor biopsies.
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