Objective: To characterize the velocity profiles (VP), relative wall distension rate (WDR) and wall shear rate (WSR) of the FDAo in the 1st, 2nd and 3rd trimesters of normal pregnancies. Methods: The MSDA system consisted of commercial ultrasound machine (Aloka SSD1400), a personal computer and a proprietary electronic board. Interrogated vessels consisted of the FDAo in a total of 36 singleton uncomplicated ongoing pregnancies. Velocity profiles, relative wall distension rate [WDR (%)] and shear rate [WSR (1/s)] were calculated over multiple consecutives cardiac cycles. The designation of arterial laminar flow was applied if one peak occurred in systole, while if > 1 peak in systole was classified as turbulent. Statistical analysis consisted of Spearman correlation. Results: FDAo displayed a laminar flow pattern throughout gestation in 31 cases, and an abnormal flow pattern in 5 cases (2 cases of turbulent flow, and 3 cases of downstream flow). Interestingly, in these 5/31 (14%) of cases, the conventional Doppler analysis was normal. Mean WDR[%] was correlated with gestational age and fetal growth (2.7 ±1.8, rs = 0.471p < 0.01) with linear regression with standardized coefficient of 0.4 (p < 0.01). In contrast, mean WSR (432 ±191) remained constant throughout gestation, beginning at 6 wks. Conclusion: Real time velocity profile analysis of the FDAo is now possible using MSDA and GASP software. This novel technology is more sensitive than conventional Doppler in detecting patterns other than pseudo‐laminar flow. Interestingly, we have found that relative WDR changes over time during gestation, which may be secondary to adaptive vascular and autonomic responses and the evolving composition of the vessel wall, particularly with respect to elastin. These parameters are being evaluated in ongoing studies to determine their relationship, if any, to placentation abnormalities and fetal complications, such as fetal anemia.
P13.21: Velocity profile characteristics of fetal descending aorta (FDAo) by global acquisition and signal processing (GASP) software for multigate spectral Doppler analysis (MSDA) / Urban, G.; Ricci, S.; Patrizio, P.; Guidi, F.; Vergani, P.; Copel, J. A.; Sanguineti, F.; Paidas, M.. - In: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. - ISSN 0960-7692. - ELETTRONICO. - 28:(2006), pp. 593-593. (Intervento presentato al convegno 16th World Congress on Ultrasound in Obstetrics and Gynecology) [10.1002/uog.3705].
P13.21: Velocity profile characteristics of fetal descending aorta (FDAo) by global acquisition and signal processing (GASP) software for multigate spectral Doppler analysis (MSDA)
Ricci, S.;Guidi, F.;
2006
Abstract
Objective: To characterize the velocity profiles (VP), relative wall distension rate (WDR) and wall shear rate (WSR) of the FDAo in the 1st, 2nd and 3rd trimesters of normal pregnancies. Methods: The MSDA system consisted of commercial ultrasound machine (Aloka SSD1400), a personal computer and a proprietary electronic board. Interrogated vessels consisted of the FDAo in a total of 36 singleton uncomplicated ongoing pregnancies. Velocity profiles, relative wall distension rate [WDR (%)] and shear rate [WSR (1/s)] were calculated over multiple consecutives cardiac cycles. The designation of arterial laminar flow was applied if one peak occurred in systole, while if > 1 peak in systole was classified as turbulent. Statistical analysis consisted of Spearman correlation. Results: FDAo displayed a laminar flow pattern throughout gestation in 31 cases, and an abnormal flow pattern in 5 cases (2 cases of turbulent flow, and 3 cases of downstream flow). Interestingly, in these 5/31 (14%) of cases, the conventional Doppler analysis was normal. Mean WDR[%] was correlated with gestational age and fetal growth (2.7 ±1.8, rs = 0.471p < 0.01) with linear regression with standardized coefficient of 0.4 (p < 0.01). In contrast, mean WSR (432 ±191) remained constant throughout gestation, beginning at 6 wks. Conclusion: Real time velocity profile analysis of the FDAo is now possible using MSDA and GASP software. This novel technology is more sensitive than conventional Doppler in detecting patterns other than pseudo‐laminar flow. Interestingly, we have found that relative WDR changes over time during gestation, which may be secondary to adaptive vascular and autonomic responses and the evolving composition of the vessel wall, particularly with respect to elastin. These parameters are being evaluated in ongoing studies to determine their relationship, if any, to placentation abnormalities and fetal complications, such as fetal anemia.
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