Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain.
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain / Branca, Jacopo Junio Valerio; Pacini, Alessandra; Gulisano, Massimo; Taddei, Niccolò; Fiorillo, Claudia; Becatti, Matteo. - In: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. - ISSN 2296-634X. - ELETTRONICO. - 8:(2020), pp. 0-0. [10.3389/fcell.2020.604377]
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain
Branca, Jacopo Junio Valerio;Pacini, Alessandra;Gulisano, Massimo;Taddei, Niccolò;Fiorillo, Claudia
;Becatti, Matteo
2020
Abstract
Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain.File | Dimensione | Formato | |
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