Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity of coronary microvascular dysfunction (CMD) in CADASIL patients.
Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy / Argirò, Alessia; Sciagrà, Roberto; Marchi, Alberto; Beltrami, Matteo; Spinelli, Enrico; Salvadori, Emilia; Bianchi, Andrea; Mascalchi, Mario; Poggesi, Anna; Olivotto, Iacopo; Pescini, Francesca. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - ELETTRONICO. - (2020), pp. 0-0. [10.1111/ene.14678]
Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Argirò, Alessia;Sciagrà, Roberto;Marchi, Alberto;Beltrami, Matteo;Salvadori, Emilia;Bianchi, Andrea;Mascalchi, Mario;Poggesi, Anna;Olivotto, Iacopo;Pescini, Francesca
2020
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity of coronary microvascular dysfunction (CMD) in CADASIL patients.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.