Wound healing is a fundamental process for survival, the whole process involves the coordinated interaction of many different cell populations and biochemical molecules, protein proteases, growth factors, and extracellular matrix (ECM) components. Mechanical factors play a critical role during tissue repair. Therefore unloading conditions represent a unique tool to increase our knowledge of wound healing biomechanics. A study on Hirudo Medicinalis wounded on the back and the sutured is used in experiments in real and modeled microgravity. The results demonstrated that microgravity induces a delay in wound closure and repair processes as shown by altered epithelium formation, matrix composition and organization.
Wound healing in weightlessness: an in vivo study on the medicinal leech (Hirudo medicinalis) / F. Cialdai , D. Pantalone, D. Bani, P. Romagnoli, A.M. Rizzo, F. Celotti, A. Colciago, E. Sereni, F. Ranaldi, M. Monici.. - STAMPA. - Unico:(2018), pp. 89-90. (Intervento presentato al convegno 39th Annual meeting of the International Society for Gravitational Physiology (IGPS) and European Space agency meets Health initiative tenutosi a Noordwijk, The Nederlands nel 18-22 Giugno 2018).
Wound healing in weightlessness: an in vivo study on the medicinal leech (Hirudo medicinalis)
F. Cialdai;D. Pantalone;D. Bani;P. Romagnoli;E. Sereni;F. Ranaldi;
2018
Abstract
Wound healing is a fundamental process for survival, the whole process involves the coordinated interaction of many different cell populations and biochemical molecules, protein proteases, growth factors, and extracellular matrix (ECM) components. Mechanical factors play a critical role during tissue repair. Therefore unloading conditions represent a unique tool to increase our knowledge of wound healing biomechanics. A study on Hirudo Medicinalis wounded on the back and the sutured is used in experiments in real and modeled microgravity. The results demonstrated that microgravity induces a delay in wound closure and repair processes as shown by altered epithelium formation, matrix composition and organization.
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