Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma We congratulate Abou-El-Ardat and colleagues,1 who studied a series of multifocal isocitrate dehydrogenase (IDH) wild-type glioblastomas (GBMs) from 6 patients and proved their monoclonal origin. On the contrary, we have come across a case of a synchronous occurrence of a high-grade and a low-grade glioma (LGG) with a discordant IDH mutational status, suggesting an independent origin
Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma / Lombardi G, D.P.A.. - In: NEURO-ONCOLOGY. - ISSN 1523-5866. - ELETTRONICO. - (2018), pp. 1142-1143. [doi:10.1093/neuonc/noy080]
Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma.
Della Puppa A;
2018
Abstract
Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma We congratulate Abou-El-Ardat and colleagues,1 who studied a series of multifocal isocitrate dehydrogenase (IDH) wild-type glioblastomas (GBMs) from 6 patients and proved their monoclonal origin. On the contrary, we have come across a case of a synchronous occurrence of a high-grade and a low-grade glioma (LGG) with a discordant IDH mutational status, suggesting an independent origin
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