Background: Rising number of multidrug-resistant human pathogens demands novel antibiotics: to this aim, unexplored natural sources are investigated to find new compounds. In this context, bacteria associated to medicinal plants, including Phragmites australis, might represent an important source of antimicrobial compounds. Materials & methods: In the present work, 21 bacterial endophytes isolated from P. australis roots were tested, by cross-streaking, for their inhibitory activity against 36 multidrug-resistant pathogens isolated from food, clinical patients and hospitals. Results & conclusion: Seven endophytes, belonging to Pseudomonas and Stenotrophomonas, were able to inhibit the growth of most of the target strains. In conclusion, this preliminary work could pave the way for the discovery of new antibiotics against superbugs.

Antibacterial activity of bacteria isolated from Phragmites australis against multidrug-resistant human pathogens / Delfino V.; Calonico C.; Lo Nostro A.; Castronovo L.M.; Del Duca S.; Chioccioli S.; Coppini E.; Fibbi D.; Vassallo A.; Fani R.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - STAMPA. - 16:(2021), pp. 291-303. [10.2217/fmb-2020-0244]

Antibacterial activity of bacteria isolated from Phragmites australis against multidrug-resistant human pathogens

Delfino V.;Calonico C.;Lo Nostro A.;Del Duca S.;Chioccioli S.;Vassallo A.;Fani R.
2021

Abstract

Background: Rising number of multidrug-resistant human pathogens demands novel antibiotics: to this aim, unexplored natural sources are investigated to find new compounds. In this context, bacteria associated to medicinal plants, including Phragmites australis, might represent an important source of antimicrobial compounds. Materials & methods: In the present work, 21 bacterial endophytes isolated from P. australis roots were tested, by cross-streaking, for their inhibitory activity against 36 multidrug-resistant pathogens isolated from food, clinical patients and hospitals. Results & conclusion: Seven endophytes, belonging to Pseudomonas and Stenotrophomonas, were able to inhibit the growth of most of the target strains. In conclusion, this preliminary work could pave the way for the discovery of new antibiotics against superbugs.
2021
16
291
303
Delfino V.; Calonico C.; Lo Nostro A.; Castronovo L.M.; Del Duca S.; Chioccioli S.; Coppini E.; Fibbi D.; Vassallo A.; Fani R.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1235096
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